Atletico Madrid arrive at RCDE Stadium on a five-match winning run, 11 points clear of mid-table Espanyol in La Liga.
Real Betis host FC Porto in the UEFA Champions League League Stage on Wednesday, with three points separating the sides after their opening fixtures.
The Argentine centre-back singled out technical director Jason Wilcox in a searing post-match television interview that drew an immediate rebuke from Wayne Rooney.
